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折扣/货期| 货号：CHI-MF-110LYVE1-C050 | 规格：50 ug | 目录价：￥4620 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
LYVE-1 (mouse):Fc (mouse) (rec.)
别名:
Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1
产品描述:
Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1 (LYVE-1) is a 60-kDa type I transmembrane glycoprotein that is a member of the Link Protein superfamily. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. It is often used as a marker of lymphatic endothelia. LYVE-1 is expressed on both the lumenal and ablumenal surfaces of lymphatic endothelium, and also on hepatic blood sinusoidal endothelia. This expression pattern, combined with studies showing that LYVE-1 can support cellular HA internalization in vitro, may suggest LYVE-1 participation in HA internalization for degradation, or transport of HA from tissues into the lumen of lymphatic vessels. LYVE-1-directed HA localization to lymphatic surfaces might also affect aspects of the immune response or tumor metastases. HA binding to CD44 can still occur in the presence of LYVE-1 in vitro. Therefore, LYVE-1-directed HA localization to lymphatics could provide a substrate for transmigrating CD44+ leukocytes or tumor cells. In addition to hepatic and lymphatic endothelia, some expression of LYVE-1 has been reported on Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium.
宿主来源:
HEK 293 cells
保存温度:
+4°C
运输温度:
BI
预期分子量:
~60-85kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
产地:
瑞士
纯度:
>98% (SDS-PAGE)
内毒素水平:
<1EU/mg protein (LAL test; Lonza).
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