CD3 epsilon antibody [145-2C11]-单抗-深圳欣博盛生物科技有限公司

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CD3 epsilon antibody [145-2C11]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX14351

规格：500μg

目录价：￥4200

产品详情

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产品名称:

CD3 epsilon antibody [145-2C11]

别名:

CD3 antigen, epsilon polypeptide , AI504783 , CD3 , CD3epsilon , T3e

反应种属:

Mouse

宿主来源:

Armenian Hamster

实验应用:

Activation, Depletion, FCM, ICC/IF, IHC-Fr, IP, Neutralizing /Inhibition, WB

靶标/特异性:

The complete 145-2C11 antibody is commonly used to stimulate T cells in vitro however, when used in vivo activation of resting T cells results in cytokine release and toxicity caused by Ab-mediated cross-linking of T cells and Fcγ receptor-bearing cells. To avoid these complications non-Fc receptor binding F(ab’)2 fragments of the 145-2C11 antibody are commonly used. This non-FcR-binding anti-CD3 induces apoptosis of Ag-activated T cells in vivo by allowing durable expression of the TCR and sustained signaling. Foxp3+ Tregs have been shown to be resistant to CD3 antibody-mediated depletion.

同种型:

IgG1

免疫原:

Mouse BM10-37 cytotoxic T cells

克隆性:

Monoclonal

克隆号:

145-2C11

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated