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折扣/货期| 货号：GTX00598-15 | 规格：100test | 目录价：￥4600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CD3 epsilon antibody [UCHT1] (APC-Cy7)
别名:
CD3e molecule , IMD18 , T3E , TCRE
产品描述:
The UCHL1 antibody reacts with the human CD45 isoform known as CD45RO, a protein tyrosine phosphatase of ≥ 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA and CD45RB.
反应种属:
Chimpanzee, Human
宿主来源:
Mouse
实验应用:
FCM
靶标/特异性:
This antibody reacts with the epsilon chain of the CD3 complex.
同种型:
IgG1
免疫原:
human thymocytes followed by Sezary T cells
克隆性:
Monoclonal
克隆号:
UCHT1
纯化方式:
Purified by affinity chromatography
偶联:
APC-Cy7
产品浓度:
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin, 0.09% Sodium azide.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
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