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折扣/货期| 货号：GTX00483-07 | 规格：100test | 目录价：￥4800 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CD35 antibody [E11] (APC)
别名:
C3BR , C4BR , CD35 , CR1 , KN , complement C3b/C4b receptor 1 (Knops blood group)
反应种属:
Human, Primate
宿主来源:
Mouse
实验应用:
FCM
同种型:
IgG1
免疫原:
Acute monocytic leukemia cells and normal blood monocytes
克隆性:
Monoclonal
克隆号:
E11
纯化方式:
Purified by size-exclusion chromatography
偶联:
APC
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
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