CD8 antibody [SK1] (APC)-单抗-深圳欣博盛生物科技有限公司

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CD8 antibody [SK1] (APC)

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX01468-07

规格：100test

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

CD8 antibody [SK1] (APC)

别名:

CD8 , CD8A , CD8a molecule , Leu2 , MAL , p32 , CD8 alpha , CD8B , CD8B1 , CD8b molecule , LEU2 , LY3 , LYT3 , P37 , CD8 beta

产品描述:

The SK1 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.The SK1 antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells. It is cross-reactive with CD8 in several non-human species, including Baboon, Chimpanzee, Cynomolgus and Rhesus. If used together with an alternative Anti-Human CD8a clone, RPA-T8, the SK1 antibody will not block binding of RPA-T8 to CD8a.

反应种属:

African green monkey, Baboon, Chimpanzee, Cynomolgus monkey, Human, Pig-tailed macaque, Rhesus Monkey, Sooty Mangabey

宿主来源:

Mouse

实验应用:

FCM

同种型:

IgG1

克隆性:

Monoclonal

克隆号:

SK1