CLACP antibody-多抗-深圳欣博盛生物科技有限公司

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CLACP antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX70471

规格：100μg

目录价：￥5000

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

CLACP antibody

别名:

collagen type XXV alpha 1 chain , AMY , CFEOM5 , CLAC , CLAC-P , CLACP

反应种属:

Human

宿主来源:

Rabbit

实验应用:

ELISA, WB

靶标/特异性:

Reacts with residues 171-183 [NHGFLSADQQLIK] of the NC2-1 region of human and mouse CLAC-P. Detects bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cerebral amyloid angiopathy.

同种型:

IgG

免疫原:

Synthetic peptide: NHGFLSADQQLIK, corresponding to amino acids 171-183 of human and mouse CLACP.

克隆性:

Polyclonal

克隆号:

纯化方式:

Affinity purified IgG

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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