Copper Transporting ATPase 1 Antibody: Biotin-单抗-深圳欣博盛生物科技有限公司

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Copper Transporting ATPase 1 Antibody: Biotin

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-398D-BI

规格：100 µg

目录价：￥4863.6

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Copper Transporting ATPase 1 Antibody: Biotin

别名:

ATP7A Antibody, ATP 7A Antibody, ATPase Cu transporting Antibody, DSMAX Antibody, FLJ17790 Antibody, MC1 Antibody, MC 1 Antibody, MK Antibody, MNK Antibody, OHS Antibody, Copper pump 1 Antibody, Menke Antibody, OTTHUMP00000062077 Antibody, SMAX3 Antibody, ATPase copper transporting alpha polypeptide Antibody, ATPase Cu++ transporting alpha polypeptide (Menkes syndrome) Antibody, Copper transporting ATPase 1 Antibody, Cu++ transporting P type ATPase Antibody, Menkes disease associated protein Antibody, Menkes syndrome Antibody

产品描述:

Mouse Anti-Human Copper Transporting ATPase 1 Monoclonal IgG2b

反应种属:

Human | Mouse | Rat

宿主来源:

Mouse

实验应用:

WB | IHC | ICC/IF | IP

靶标/特异性:

Detects ~180kDa in rat brain membrane preparations.

同种型:

IgG2b

推荐稀释度:

WB (1:500), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

免疫原:

Synthetic peptide amino acids 42-61 (cytoplasmic C-terminus) of human Copper- transporting ATPase1

免疫原种属:

Human

克隆性:

Monoclonal

克隆号:

L60/4 (Formerly sold as S60-4)

纯化方式:

Protein G Purified

偶联:

Biotin

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-trans locating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood. Mutations in the ATP7B gene lead to the autosomal recessive disorder, Wilson disease, characterized by neurological symptoms and hepatic damage.

Accession #:

NP_000043.3