COX10 antibody, Internal-多抗-深圳欣博盛生物科技有限公司

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COX10 antibody, Internal

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX46575

规格：50μg

目录价：￥6000

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

COX10 antibody, Internal

别名:

cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10

反应种属:

Human

宿主来源:

Rabbit

实验应用:

同种型:

IgG

免疫原:

A synthetic peptide corresponding to an Internal region of Human COX10

克隆性:

Polyclonal

克隆号:

纯化方式:

Affinity Purified

偶联:

Unconjugated

产品浓度:

0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 2% Sucrose, 0.09% Sodium azide.

生产商:

GeneTex

功能与背景:

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]

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