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折扣/货期| 货号：V8996-100UG | 规格：100 ug | 目录价：￥6652.1 |
| 货号：V8996-20UG | 规格：20 ug | 目录价：￥3082.1 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
COX2 Antibody / PTGS2
产品描述:
Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (COX2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and COX2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. COX2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P
同种型:
Mouse IgG2a, kappa
免疫原:
A portion of amino acids 442-572 was used as the immunogen for the COX2 antibody.
克隆性:
Monoclonal (mouse origin)
克隆号:
COX2/2377
纯化方式:
Protein A/G affinity
保存温度:
Aliquot the COX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Purified
存储溶液:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
产地:
美国
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