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折扣/货期| 货号：GTX04768 | 规格：100μl | 目录价：￥5600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CXCR2 antibody
别名:
CD182,CDw128b,CMKAR2,CXC motif chemokine receptor 2,CXCR2,IL8R2,IL8RA,IL8RB,IL-8 RB,C-X-C motif chemokine receptor 2
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
IHC-Fr, IHC-P, WB
同种型:
IgG
免疫原:
KLH conjugated synthetic peptide derived from human CXCR2 (316-360)
克隆性:
Polyclonal
克隆号:
纯化方式:
Protein A purified
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
41
产品形式:
Liquid
存储溶液:
0.01M TBS, 1% BSA, 50% Glycerol, 0.02% Proclin300.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
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