官网链接
折扣/货期| 货号：GTX22096 | 规格：100μl | 目录价：￥9200 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Cyclin B1 antibody
别名:
cyclin B1 , CCNB
反应种属:
Human
宿主来源:
Rabbit
实验应用:
ELISA, IHC-P, IP, WB
靶标/特异性:
No reaction was observed against other related cyclins.
同种型:
IgG
免疫原:
Full length fusion protein corresponding to the human gene.
克隆性:
Polyclonal
克隆号:
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
48
产品形式:
Liquid
存储溶液:
Filtered-steriled serum, 0.01% Sodium azide.
生产商:
GeneTex
功能与背景:
In mammals, cyclin B associates with inactive p34 cdc2 which facilitates phosphorylation of p34 cdc2 at aa 14 Thr and 15 Tyr. This maintains the inactive state until the end of G2 phase. The inactive cyclin B p34 cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34 cdc2 rendering the complex active at the G2 / M boundary. This mitotic kinase complex remains active until the metaphase / anaphase transition when cyclin B is degraded. This degradation process is ubiquitin dependent and is necessary for the cell to exit mitosis. Therefore, cyclin B p34 cdc2 plays a critical role in G2 to M transition.
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