Cyclin D1 antibody-多抗-深圳欣博盛生物科技有限公司

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Cyclin D1 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX21224

规格：100μl

目录价：￥9200

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Cyclin D1 antibody

别名:

cyclin D1 , BCL1 , D11S287E , PRAD1 , U21B31

反应种属:

Human

宿主来源:

Rabbit

实验应用:

ELISA, IP, WB

靶标/特异性:

No reaction was observed against other related cyclins.

同种型:

IgG

免疫原:

Full length fusion protein corresponding to the human gene sequence.

克隆性:

Polyclonal

克隆号:

纯化方式:

Unpurified

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

Filtered-steriled serum, 0.01% Sodium azide.

生产商:

GeneTex

功能与背景:

Cyclin D1 (also known as G1/S-specific cyclin D1, PRAD1 oncogene, BCL-1 oncogene, and PRAD1: parathyroid adenomatosis 1) is encoded by a gene that belongs to the highly conserved cyclin family. Cyclins are characterized by a dramatic periodicity in protein abundance throughout the cell cycle and function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

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