Cyclin E1 (phospho Thr395) antibody-多抗-深圳欣博盛生物科技有限公司

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Cyclin E1 (phospho Thr395) antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX50722

规格：100μl

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Cyclin E1 (phospho Thr395) antibody

别名:

cyclin E1 , CCNE , pCCNE1

反应种属:

Human

宿主来源:

Rabbit

实验应用:

同种型:

IgG

免疫原:

Peptide sequence around phosphorylation site of threonine 395 (L-L-T(p)-P-P)derived from human Cyclin E1.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

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