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折扣/货期| 货号：GTX16570 | 规格：100μg | 目录价：￥7500 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Cytokeratin 5 + 14 antibody [16.4]
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC (Formalin), IHC-Fr, WB
同种型:
IgG2a
免疫原:
Tissue / cell preparation (cytokeratin enriched extract of feline tongue epithelium).
克隆性:
Monoclonal
克隆号:
16.4
纯化方式:
IgG fraction
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.08% Sodium azide.
生产商:
GeneTex
功能与背景:
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non-keratinizing cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis.Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.
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