官网链接
折扣/货期| 货号：GTX10524 | 规格：50μl | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
DAP Kinase 1 (phospho Ser308) antibody [DKPS308]
别名:
death associated protein kinase 1 , DAPK , ROCO3
反应种属:
Human
宿主来源:
Mouse
实验应用:
ELISA, IP, WB
同种型:
IgG1
免疫原:
Phosphopeptide corresponding to amino acids 303-312 (pSer308) of human DAP-kinase, conjugated to KLH.
克隆性:
Monoclonal
克隆号:
DKPS308
纯化方式:
Purified immunoglobulin
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
Various apoptotic signals use Death Associated Protein Kinase (DAPK) as a downstream effector in different cell types. DAPK is a positive mediator of apoptosis and is widely expressed in many tissues of embryonic and adult origin. DAPK is a Ca2+/calmodulin dependent Ser/Thr kinase that associates with microfilaments. The protein is composed of a multidomain structure. It has a subdomain typical of serine/threonine kinases, a Ca2+/calmodulin regulatory domain, eight ankyrin repeats followed by two P-loop motifs and a typical death domain module. It contains two auto-inhibitory domains one of them Ca2+/calmodulin dependent. In the absence of this latter domain, DAPK is constitutively active. DAPK activity is also regulated by phosphorylation. DAPK was found to be negatively regulated by autophosphorylation at Ser308 which is in the calmodulin regulatory domain. This autophosphorylation, which occurs in cells at the basal state, lowers the affinity of DAPK for calmodulin and thus the kinase is inactive. Under some apoptotic conditions DAPK undergoes dephosphorylation. As a consequence, it binds to calmodulin with higher affinity, becomes activated, phosphorylates its downstream substrate proteins, and mediates apoptosis. Monoclonal antibodies specific for Phospho DAP-Kinase (pSer308) are important tools for studying the mechanism of DAPK activation in apoptosis.
您可能感兴趣的产品
4-hydroxy Nonenal Monoclonal Antibody (HNEJ-1/Clone IG10) - HRP Conjugated
货号：45025
ICAM4 antibody [HL5612]
货号：GTX646294
14-3-3 epsilon antibody [HL5606]
货号：GTX646288
Ras (Q61H mutant) antibody [HL5601]
货号：GTX646283
ALDH1L1 antibody [HL5536]
货号：GTX646210
AAV13 Capsid protein VP1 + VP2 + VP3 antibody [HL5535]
货号：GTX646198
ESAM antibody [HL5518]
货号：GTX646181
CD79a antibody [HL5516]
货号：GTX646179
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询