Dichloroacetate [CDA] . sodium salt-抑制剂-深圳欣博盛生物科技有限公司

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Dichloroacetate [CDA] . sodium salt

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3684-G001

规格：1 g

目录价：￥600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Dichloroacetate [CDA] . sodium salt

别名:

Dichloroacetic acid sodium salt; Bichloroacetic acid; BCA

产品描述:

Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor, consequently activating pyruvate dehydrogenase (PDH). Decreases glycolysis. Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Antitumor agent. Decreases tumor growth in vitro and in vivo. Induces mitochondrial-dependent apoptosis. Useful agent for immunometabolism research. Glucose entering the cell is metabolized by glycolysis to pyruvate. Most of the pyruvate in non-cancerous cells enters the mitochondria under aerobic conditions and a small fraction is metabolized to lactate. PDH in mitochondria converts pyruvate into acetyl-CoA, which enters the TCA cycle. In cancer cells, the oxidative (mitochondrial) pathway of glucose utilization is suppressed and most of the pyruvate is converted into lactate (Warburg effect). The relative activities of LDH and PDH therefore determine the fate of pyruvate. PDK inhibits PDH through phosphorylation and regulates its activities, resulting in suppression of the TCA cycle and mitochondrial respiration. This renders PDK a promising target for the treatment of various cancers.

保存温度:

+20°C

运输温度:

Ambient

预期分子量:

127.9 . 23.0

产品形式:

solid

产地:

瑞士

纯度:

>98%