DRAM antibody-多抗-深圳欣博盛生物科技有限公司

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DRAM antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX85484

规格：100μg

目录价：￥6200

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

DRAM antibody

别名:

DNA damage regulated autophagy modulator 1 , DRAM

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

ELISA, IHC-P, WB

靶标/特异性:

This antibody is specific for DRAM C-Terminus

同种型:

IgG

免疫原:

DRAM antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human DRAM.The immunogen is located within amino acids 170 - 220 of DRAM.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

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