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折扣/货期| 货号：GTX22900 | 规格：100μg | 目录价：￥5600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
EEA1 antibody
别名:
early endosome antigen 1 , A430109M19Rik , B230358H09Rik , ZFYVE2
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
FCM, ICC/IF, IHC, WB
同种型:
IgG
免疫原:
Synthetic peptide corresponding to residues T(1391) P S S K K P V R V C D A C F N D L Q G(1410) of human EEA1.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
161
产品形式:
Liquid
存储溶液:
PBS, 0.1% BSA, 0.05% Sodium azide.
生产商:
GeneTex
功能与背景:
Early endosomal antigen 1 (EEA1) is a 162 kDa membrane bound protein component specific to the early endosome and is essential for fusion between early endocytic vesicles. Early endosomes are cytoplasmic compartments which fuse with endocytic vesicles for redistribution of extracellular compounds to alternate destinations. Zinc-finger-like domains, reminiscent of those found in nucleic acid binding proteins, are located in the amino and carboxyl-terminal domains of EEA1. The carboxyl-terminal zinc-finger-like-domain is conserved in several other non-nuclear proteins, some of which are also involved in intracellular protein trafficking. In addition, this domain is an authentic zinc-binding domain and is critical to the intracellular localization of EEA1. Membrane association of EEA1 has been shown dependent on phosphatidyl 3-kinase activity, inhibitors of which cause EEA1 to dissociate from early endosomes.
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