eIF3e antibody-多抗-深圳欣博盛生物科技有限公司

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eIF3e antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX48712

规格：50μg

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

eIF3e antibody

别名:

eukaryotic translation initiation factor 3, subunit E , 48kDa , Eif3s6 , Int6 , eIF3-p46 , eIF3-p48

反应种属:

Human, Monkey, Mouse

宿主来源:

Rabbit

实验应用:

ELISA, WB

同种型:

IgG

免疫原:

Synthetic peptide corresponding to a region near the C-terminus of mouse EIF3S6/Int6.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography.

偶联:

Unconjugated

产品浓度:

0.8 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.

生产商:

GeneTex

功能与背景:

Int6 is a candidate tumor suppressor in multiple neoplasms, and in particular, breast and lung cancers. The Int6 locus was initially identified as a common insertion site (CIS) in a genetic screen for transforming sequences in a breast cancer mouse model system. Insertion of mouse mammary tumor virus (MMTV) into this locus results in the production of an amino-terminal truncated gene product. Expression of the truncated Int6 product corresponds to cellular transformation in both in vivo and in vitro systems. This gene product plays a role in regulating translation initiation and is a component of the eIF3 translation initiation complex.There is evidence that suggests that Int6 may impart a negative role in the general translational machinery while promoting an increase in the expression of a subset of stress-responsive genes. Taken together, it is of great interest to further study the mechanism by which Int6 is involved in regulating cell growth.

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