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折扣/货期| 货号：SMC-240D-APC | 规格：100 µg | 目录价：￥4926.6 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ENaC beta Antibody: APC
别名:
SCNN1B Antibody, Amiloride sensitive sodium channel subunit beta Antibody, Amiloride-sensitive sodium channel beta-subunit Antibody, Beta ENaC Antibody, Beta NaCH Antibody, ENaC beta Antibody, ENaCB Antibody, Epithelial Na(+) channel subunit beta Antibody, Epithelial Na+ channel beta subunit Antibody, Epithelial Na+ channel subunit beta Antibody, Epithelial sodium channel beta 2 subunit Antibody, Epithelial sodium channel beta 3 subunit Antibody, Nonvoltage gated sodium channel 1 beta subunit Antibody, Nonvoltage gated sodium channel 1 subunit beta Antibody, Nonvoltage-gated sodium channel 1 beta subunit Antibody, SCNEB Antibody, SCNN 1B Antibody, Sodium channel nonvoltage gated 1 beta (Liddle syndrome) Antibody, Sodium channel nonvoltage gated 1 beta Antibody
产品描述:
Mouse Anti-Rat ENaC beta Monoclonal IgG1
反应种属:
Mouse
宿主来源:
Mouse
实验应用:
WB | IHC
靶标/特异性:
Detects ~87kDa.
同种型:
IgG1
推荐稀释度:
WB (1:1000); IHC (1:150); optimal dilutions for assays should be determined by the user.
免疫原:
Synthetic peptide from the C-terminal of Rat ENaC beta (aa. 617-638)
免疫原种属:
Rat
克隆性:
Monoclonal
克隆号:
7B8
纯化方式:
Protein G Purified
偶联:
APC
产品浓度:
1 mg/ml
保存温度:
Conjugated antibodies should be stored according to the product label
运输温度:
Blue Ice or 4ºC
存储溶液:
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
产地:
加拿大
功能与背景:
The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2).
ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta, and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
Accession #:
NP_036780
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