EphA8 antibody-多抗-深圳欣博盛生物科技有限公司

首页产品中心多抗

EphA8 antibody

买大送小新年开门红～买大送小，好礼四选一！

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX10615

规格：50μg

目录价：￥8800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

EphA8 antibody

别名:

Eph receptor A8 , AW047546 , Eek , Hek3 , mKIAA1459

反应种属:

Mouse

宿主来源:

Goat

实验应用:

ELISA, WB

同种型:

IgG

免疫原:

purified recombinant mouse EphA8 extracellular domain.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

111

产品形式:

Liquid

存储溶液:

PBS, no preservatives.

生产商:

GeneTex

功能与背景:

EphA8, also known as Eek and Hek3, is a member of the Eph receptor family, which binds members of the ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region is a juxtamembrane region with two tyrosines, the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the C-terminus, the latter including one conserved tyrosine. The calculated molecular mass of the reduced mouse EphA8/Fc monomer is 84.2 kDa, but as a result of glycosylation, recombinant EphB8/Fc migrates as an approximately 100-120 kDa protein under reducing conditions in SDS-PAGE. Ligand recognition and binding leads to activation of the intrinsic kinase activity. EphA8 binds to Ephrin-A2, Ephrin-A3, and Ephrin-A5. Full length human and rat homolgs have not been successfully cloned. Only membrane-bound or Fc-clustered ligands have been shown to activate the receptor in vitro. Soluble monomeric ligands can bind the receptor, but do not induce receptor autophosphorylation and activation.The ephrin ligands and eph receptors display reciprocal expression in vivo. Developing and adult neural tissue express nearly all of the Eph receptors and ephrin ligands. Ephs and ephrins play a significant role in angiogenesis.

您可能感兴趣的产品

Complement C3 antibody

货号：88R-7581

Rabbit Lambda light chain antibody (Prediluted for IHC)

货号：75R-1046

Rabbit Kappa light chain antibody (Prediluted for IHC)

货号：75R-1045

Streptococcus Group A antibody