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折扣/货期| 货号：GTX10616 | 规格：50μg | 目录价：￥6600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
EphB2 antibody
别名:
Eph receptor B2 , Cek5 , Drt , ETECK , Erk , Hek5 , Nuk , Prkm5 , Qek5 , Sek3 , Tyro5
反应种属:
Mouse
宿主来源:
Goat
实验应用:
Dot, ELISA
靶标/特异性:
In immunoblotting, the antibody exhibits ~5% cross-reactivity with recombinant rat EphB1 and EphA5, recombinant mouse EphA8, EphB6, EphA3, EphA4, EphA7, EphA2, EphB3, and recombinant human EphA1.
同种型:
IgG
免疫原:
Purified recombinant mouse EphB2 extracellular domain expressed in NSO cells.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
EphB2, also known as Cek5, Hek5, Tyro5, Se3, Nuk, Erk, Qek2, and Drt, is a member of the Eph receptor family, which binds members of the ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region contains a juxtamembrane motif with two tyrosines, which are the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxyl terminus, which includes one conserved tyrosine. The recombinant mouse EphB2 used for the testing of this antibody consists of the extracellular domain of mouse EphB2 (amino acids 1-548)1 fused by means of a polypeptide linker to the Fc portion of human IgG1 that is histidine-tagged at the C-terminus. N-terminal sequencing indicates that recombinant mouse EphB2 has Val 27 at the amino terminus. The calculated molecular mass of the reduced protein is approximately 85.3 kDa, but as a result of glycosylation, recombinantEphB2/Fc migrates as a 100-110 kDa protein under reducing conditions in SDS-PAGE. EphB2 binds to ephrin-B1, ephrin-B2, and ephrin-B3. Human and mouse EphB3 extracellular domains share approximately 99% homology. Ligand recognition and binding leads to activation of intrinsic kinase activity. Only membrane-bound or Fc-clustered ligands have been shown to activate the receptor in vitro. Soluble monomeric ligands can bind the receptor, but do not induce receptor autophosphorylation and activation. The ephrin ligands and Eph receptors display reciprocal expression in vivo. Developing and adult neural tissue express nearly all of the Eph receptors and ephrin ligands. Ephs and ephrins play a significant role in angiogenesis.
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