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折扣/货期| 货号：SYN-3044-M001 | 规格：1 mg | 目录价：￥1204 |
| 货号：SYN-3044-M005 | 规格：5 mg | 目录价：￥2268 |
| 货号：SYN-3044-M010 | 规格：10 mg | 目录价：￥3780 |
| 货号：SYN-3044-M050 | 规格：50 mg | 目录价：￥11340 |
| 货号：SYN-3044-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
EPZ015666
别名:
GSK3235025; YQ36286; (S)-N-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
产品描述:
Protein arginine methyltransferase-5 (PRMT5) is reported to have a role in diverse cellular processes, including tumorigenesis and its overexpression is observed in cell lines and primary patient samples derived from lymphomas, particularly mantle cell lymphoma (MCL). EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity in biochemical assays with an IC50 of 22nM and broad selectivity against a panel of other histone methyltransferases. Treatment of MCL cell lines with EPZ015666 led to inhibition of SmD3 methylation and cell death. Oral dosing with EPZ015666 demonstrated dose-dependent antitumor activity in multiple MCL xenograft models. EPZ015666 represents a validated chemical probe for further study of PRMT5 biology and arginine methylation in cancer and other diseases.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
383.4
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95%
CAS号:
1616391-65-1
分子式:
C20H25N5O3
溶解度:
Soluble in DMSO.
促销活动
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