Factor XII antibody-多抗-深圳欣博盛生物科技有限公司

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Factor XII antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX79764

规格：1mg

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Factor XII antibody

别名:

F12,HAE3,HAEX,HAF,coagulation factor XII,FA12,Factor XII

反应种属:

Human

宿主来源:

Sheep

实验应用:

ELISA, WB

同种型:

IgG

免疫原:

Full length native protein (purified) (Human).

克隆性:

Polyclonal

克隆号:

纯化方式:

Protein G purified

偶联:

Unconjugated

产品浓度:

10 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

50mM Sodium Phosphate, 100mM NaCl, 1mM EDTA, no preservatives.

生产商:

GeneTex

功能与背景:

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]

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