Fas Ligand antibody [NOK-1]-单抗-深圳欣博盛生物科技有限公司

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Fas Ligand antibody [NOK-1]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX01476

规格：100μg

目录价：￥2500

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Fas Ligand antibody [NOK-1]

别名:

Fas ligand , ALPS1B , APT1LG1 , APTL , CD178 , CD95L , FASL , FASLG , TNFSF6 , TNLG1A , fasL , Fas Ligand , Fasligand , CD95 ligand

产品描述:

The NOK-1 antibody reacts with human CD178 (Fas ligand) in both membrane bound and soluble forms. Fas ligand is a 40 kDa transmembrane glycoprotein, a member of the TNF-α family, and is expressed by activated T and NK cells, neutrophils, and monocytes. Interactions between CD178 (Fas ligand) and CD95 (Fas) induce a program of apoptosis and play a key role in immune regulation and homeostasis. The extracellular domain of human CD178 can be cleaved from the surface by matrix metalloproteinases (MMPs) resulting in a 26 kDa soluble protein.

反应种属:

Human

宿主来源:

Mouse

实验应用:

ELISA, FCM, IP, Neutralizing/Inhibition, WB

同种型:

IgG1

克隆性:

Monoclonal

克隆号:

NOK-1

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

10mM NaH₂PO₄, 150mM NaCl, 0.09% Sodium azide.

生产商:

GeneTex

功能与背景:

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

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