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折扣/货期| 货号：GTX25668 | 规格：100μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
FE65 antibody
别名:
amyloid beta (A4) precursor protein-binding, family B, member 1 , Fe65 , Rir
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
FCM, ICC/IF, WB
靶标/特异性:
This antibody does not detect endogenous levels of Fe65.
同种型:
IgG
免疫原:
Synthetic Peptide: P(352) Q E E E K L S Q R N A N P G I K C(369)
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
77
产品形式:
Liquid
存储溶液:
PBS, 0.1% BSA, 0.05% Sodium azide.
生产商:
GeneTex
功能与背景:
The major transcript of the Fe65 gene is a neuron-specific mRNA that encodes a nuclear protein whose amino-terminal domain strongly activates the transcription of reporter genes. Fe65 has been implicated in a regulatory and cell signaling mechanism because it contains two different motifs involved in protein binding; a WW domain (a variant of Src homology 3 domains) and a phosphotyrosine interaction domain (PID). Interestingly, the PID domain binds to the same motif present in the conserved cytoplasmic domains of the beta PP and beta PP-like proteins. RNA analyses revealed that Fe65 is predominantly expressed in the brain and in the regions most affected by Alzheimer’s disease-associated neuropathology.
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