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折扣/货期| 货号：GTX20830 | 规格：125μg | 目录价：￥5600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
FGFR1 antibody [M1C4]
别名:
BFGFR , CD331 , CEK , ECCL , FGFBR , FGFR1 , FLG , FLT2 , HBGFR , HH2 , HRTFDS , KAL2 , NSAM , OGD , bFGFR1 , fibroblast growth factor receptor 1 , FGF Receptor 1
反应种属:
Human
宿主来源:
Mouse
实验应用:
IP, WB
靶标/特异性:
This antibody reacts with the COOH-terminus of unique NH2-terminal Ig loop of FGFr1. Epitope is within the sequence between glu75 and ser119 of FGFr1α. Epitope is masked in undenatured FGFr1α.
同种型:
IgG1
免疫原:
Recombinant human ectodomain of FGFr1α expressed in E. coli beginning with pro23; antigen contained NH2-terminal gly-ser-pro-gly- ile and COOH-terminal glu-phe sequences.
克隆性:
Monoclonal
克隆号:
M1C4
纯化方式:
Protein G purified
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
92
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
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