FOXA1 antibody [3A8]-单抗-深圳欣博盛生物科技有限公司

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FOXA1 antibody [3A8]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX84487

规格：100μl

目录价：￥7300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

FOXA1 antibody [3A8]

别名:

forkhead box A1 , HNF3A , TCF3A

反应种属:

Dog, Human

宿主来源:

Mouse

实验应用:

ICC/IF, WB

同种型:

IgG2b

免疫原:

Recombinant protein expressed in E.coli corresponding to amino acids 1-473 of human FOXA1

克隆性:

Monoclonal

克隆号:

3A8

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate | FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription | required for ESR1 binding to the NKX2-1 promoter in breast cancer cells | binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.

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