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折扣/货期| 货号：GTX80283-07 | 规格：100μg | 目录价：￥5100 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
FOXP3 antibody [3G3] (APC)
别名:
forkhead box P3 , JM2 , scurfin , sf
产品描述:
The 3G3 antibody reacts with mouse Foxp3, a 50-55 kDa transcription factor which is a central regulator of T cell activity and is critical for the development and function of regulatory T cells (Tregs). Foxp3 is expressed at constitutively high levels in Treg cells, which are further identified as being CD4+ CD25+. In resting conventional T cells (CD4+ CD25-) Foxp3 expression is restricted, and upon TCR activation is expressed only transiently and in a small proportion of cells. However, the growth factor TGF-beta has been shown to induce expression of Foxp3 in naïve T cells, driving their development into Foxp3+ Tregs, which are called “induced” or “adaptive” Tregs. These cells are phenotypically similar to so-called “natural” Tregs (CD4+ CD25high Foxp3+) which originate in the thymus and comprise the majority of Treg cells. Tregs are critical for maintaining peripheral tolerance and are implicated in the development of autoimmunity.
反应种属:
Human, Mouse, Rhesus Monkey
宿主来源:
Mouse
实验应用:
FCM
同种型:
IgG1
免疫原:
Full-length His-tagged recombinant murine FoxP3
免疫原种属:
Mouse
克隆性:
Monoclonal
克隆号:
3G3
纯化方式:
Purified by affinity chromatography
偶联:
APC
产品浓度:
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin, 0.09% Sodium azide.
生产商:
GeneTex
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