FOXP3 antibody [3G3] (APC)-单抗-深圳欣博盛生物科技有限公司

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FOXP3 antibody [3G3] (APC)

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX80283-07

规格：100μg

目录价：￥5100

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

FOXP3 antibody [3G3] (APC)

别名:

forkhead box P3 , JM2 , scurfin , sf

产品描述:

The 3G3 antibody reacts with mouse Foxp3, a 50-55 kDa transcription factor which is a central regulator of T cell activity and is critical for the development and function of regulatory T cells (Tregs). Foxp3 is expressed at constitutively high levels in Treg cells, which are further identified as being CD4+ CD25+. In resting conventional T cells (CD4+ CD25-) Foxp3 expression is restricted, and upon TCR activation is expressed only transiently and in a small proportion of cells. However, the growth factor TGF-beta has been shown to induce expression of Foxp3 in naïve T cells, driving their development into Foxp3+ Tregs, which are called “induced” or “adaptive” Tregs. These cells are phenotypically similar to so-called “natural” Tregs (CD4+ CD25high Foxp3+) which originate in the thymus and comprise the majority of Treg cells. Tregs are critical for maintaining peripheral tolerance and are implicated in the development of autoimmunity.

反应种属:

Human, Mouse, Rhesus Monkey

宿主来源:

Mouse

实验应用:

FCM

同种型:

IgG1

免疫原:

Full-length His-tagged recombinant murine FoxP3

免疫原种属:

Mouse