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折扣/货期| 货号：AG-40B-0133-3050 | 规格：3 x 50 ug | 目录价：￥5760 |
| 货号：AG-40B-0133-C050 | 规格：50 ug | 目录价：￥2880 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Frizzled-5 (human):Fc (human) (rec.)
别名:
FzE5; Fz-5; hFz5
产品描述:
Wnts are lipid-modified morphogens that control many processes during development, stem cell maintenance and homeostasis and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Three distinct receptor families mediate Wnt signaling: Fzs, the single-pass LRP5/6 co-receptors and the atypical tyrosine kinase receptors Ror2 and Ryk. Frizzled proteins can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Wnt/Ca2+ pathways and planar cell polarity). The cysteine-rich domain (CRD) of the frizzled receptors situated on the extracellular part of the receptor is sufficient to bind the Wnt ligands.
宿主来源:
HEK 293 cells
靶标/特异性:
Binds to human and mouse Wnt3a.
产品浓度:
1mg/ml after reconstitution
保存温度:
+4°C
运输温度:
BI
预期分子量:
~50kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Inhibits Wnt3a activation in a stoechiometric manner.
内毒素水平:
<0.01EU/µg purified protein (LAL test).
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