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折扣/货期| 货号：GTX23467 | 规格：100μl | 目录价：￥7100 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Furin antibody
别名:
FUR,FURIN,PACE,PCSK3,SPC1,furin, paired basic amino acid cleaving enzyme,Furin
反应种属:
Dog, Hamster, Human, Monkey, Mouse, Pig, Rat
宿主来源:
Rabbit
实验应用:
ICC/IF, IHC, IP, Neutralizing/Inhibition, WB
同种型:
IgG
免疫原:
Synthetic peptide: RGERTAFIKDQSAL, corresponding to amino acids 780-793 of Human Furin Convertase.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography
偶联:
Unconjugated
产品浓度:
2 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
87
产品形式:
Liquid
存储溶液:
PBS, 0.1% BSA, 0.05% sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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