GABA-B Receptor 1 Antibody: ATTO 488-单抗-深圳欣博盛生物科技有限公司

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GABA-B Receptor 1 Antibody: ATTO 488

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-403D-A488

规格：100 µg

目录价：￥4926.6

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GABA-B Receptor 1 Antibody: ATTO 488

别名:

GABA-B receptor 1 Antibody, GABA-B-R1 Antibody, GABR1_Human Antibody, Gamma aminobutyric acid receptor 1 Antibody, GB1 Antibody, GPRC3A Antibody

产品描述:

Mouse Anti-Rat GABA-B Receptor 1 Monoclonal IgG1

反应种属:

Human | Mouse | Rat

宿主来源:

Mouse

实验应用:

WB | ICC/IF

靶标/特异性:

Detects ~115kDa. No cross-reactivity against GABA(B)R2.

同种型:

IgG1

推荐稀释度:

WB (1:1000); optimal dilutions for assays should be determined by the user.

免疫原:

Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABA(B)R1

免疫原种属:

Rat

克隆性:

Monoclonal

克隆号:

N93A/49 (Formerly sold as S93A-49)

纯化方式:

Protein G Purified

偶联:

ATTO 488

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1).

Accession #:

NP_112290.2