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折扣/货期| 货号：AG-40B-0272-C050 | 规格：50 ug | 目录价：￥4800 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
GLP-1R (human) (monomer):Fc (silent) InVivoKine™
别名:
InVivoKine™; GLP-1R (human) Fc (LALA-PG) Knobs-into-Holes (human) (rec.); Glucagon-like Peptide 1 Receptor; GLP1R
产品描述:
Glucagon-like peptide 1 (GLP-1) is a 30-amino acid Incretin peptide hormone produced in the intestine by differential processing of proglucagon. Incretin hormones are gut peptides that are secreted after nutrient intake and stimulate insulin secretion together with hyperglycemia. GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) are the known incretin hormones from the upper (GIP, K cells) and lower (GLP-1, L cells) gut. GLP-1 receptors are abundant in the hypothalamus which contains projections to the hunger centers. GLP-1 decreases calorie intake, boosts feelings of satiety and encourages weight loss. GLP-1 and GIP hormones are used as drugs for weight loss in obese patients and also to lower blood sugar levels. The GLP-1R (human) (monomer):Fc (silent) InVivoKine™ is produced by using two different vectors, one encoding for the GLP-1R (human:Fc (LALA-PG) Knobs sequence (synthesizing a protein of 60kDa) and one encoding for the Fc (LALA-PG) Holes sequence (synthesizing a protein of 28kDa). Both vectors transfected into HEK293 cells produce both Fc molecules (Knobs-into-Holes technology; J.B. Ridgway, et al.; Protein Eng. 9, 617 (1996)) required for dimerization of the Fc moieties and for secretion of the final protein GLP-1R (human) (monomer):Fc (silent) InVivoKine™. The LALA-PG mutations inhibit binding to FcgammaRs and C1q while FcRn binding and Fc stability remain unaffected. InVivoKines™ are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed and manufactured by AdipoGen Life Sciences.
宿主来源:
HEK 293 cells. Produced using animal component-free medium.
靶标/特异性:
Binds to GLP-1, Semaglutide and Tirzepatide. Cross-reacts with human, mouse, rat or bovine GLP-1. The Fc contains the mutations LALA-PG that abolish the interaction between the Fc and FcgammaRs and therefore Fc undesirable effects.
产品浓度:
After reconstitution: 1mg/ml
保存温度:
+4°C
运输温度:
BI
预期分子量:
~65kDa and 28kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
内毒素水平:
<0.01 EU/µg protein (LAL test).
上一个:IL-4 (mouse) (monomer):Fc (silent) InVivoKine™
下一个:IL-11 (mouse) (monomer):Fc (silent) InVivoKine™
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