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折扣/货期| 货号：GTX11379 | 规格：100μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Glucocorticoid Receptor antibody [8E9]
别名:
nuclear receptor subfamily 3 group C member 1 , GCCR , GCR , GCRST , GR , GRL
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
ELISA, WB
靶标/特异性:
This antibody recognizes human GR, binding to an epitope between amino acids 167-176 and is therefore expected to bind all described isoforms.
同种型:
IgG1
免疫原:
26 amino acid peptide corresponding to residues 150-176 of human GCR linked to human thyroglobulin.
克隆性:
Monoclonal
克隆号:
8000000000
纯化方式:
Protein G purified
偶联:
Unconjugated
产品浓度:
1.0 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.1% BSA, 0.09% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
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