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折扣/货期| 货号：GTX26585 | 规格：1ml | 目录价：￥11800 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Glutamine Synthetase antibody
反应种属:
Brevibacterium
宿主来源:
Goat
实验应用:
ELISA, IP, WB
同种型:
IgG
免疫原:
Glutamine Synthetase collected from brevibacterium species
克隆性:
Polyclonal
克隆号:
偶联:
Unconjugated
产品浓度:
90 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
生产商:
GeneTex
功能与背景:
Glutamine Synthetase (GS) catalyzes the conversion of ammonia and glutamate to glutamine. This reaction consumes a molecule of ATP:Glutamate + NH4+ + ATP --> Glutamine + ADP + Pi. GS is found in astrocytes as an octamer of identical 45kDa subunits. The function of GS is the detoxification of brain ammonia. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer s disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. On the other hands, the level of expression of GS is increased during ischemia in vivo or hypoxia in culture.
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