GMNN Antibody / Geminin-单抗-深圳欣博盛生物科技有限公司

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GMNN Antibody / Geminin

品牌：NSJ Bio

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说明书

折扣/货期

货号：V9691-100UG	规格：100 ug	目录价：￥6414.1
货号：V9691-20UG	规格：20 ug	目录价：￥2963.1

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GMNN Antibody / Geminin

产品描述:

Geminin is a nuclear protein that regulates the initiation of DNA replication during the cell cycle. DNA replication requires the coordinated association of Cdc6 and minichromosome maintenance (MCM) proteins with chromatin. Geminin blocks this assembly of the MCM into the prereplication complex and, in turn, prevents replication from occurring. Expression of Geminin fluctuates throughout the cell cycle with Geminin levels lowest at G1. Throughout S, G2 and M phases, Geminin levels are consistently elevated followed by a decrease during mitosis. The initiation of DNA replication is dependent on the degradation of Geminin during mitosis and the absence of Geminin throughout G1 phase. Geminin degradation is mediated by the anaphase-promoting complex (APC), which specifically targets B-type cyclins and other proteins containing a destruction box motif for degradation by ubiquitin-mediated proteolysis. While geminin expression is essential in maintaining chromosomal integrity, it is frequently overexpressed in cancers and evidence suggests that it plays a significant role in tumor proliferation and progression.

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P

同种型:

Mouse IgG1, kappa

免疫原:

A portion of amino acids 71-202 was used as the immunogen for the GMNN antibody.

克隆性:

Monoclonal (mouse origin)