GPX3 antibody, Internal-多抗-深圳欣博盛生物科技有限公司

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GPX3 antibody, Internal

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX89142

规格：100μg

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GPX3 antibody, Internal

别名:

glutathione peroxidase 3 , GPx-P , GSHPx-3 , GSHPx-P

反应种属:

Human, Mouse, Pig

宿主来源:

Goat

实验应用:

IHC-Fr, IHC-P, WB

靶标/特异性:

This antibody may cross-react with epididymis-specific GPX5 and olfactory epithelium-speciific GPX6

同种型:

IgG

免疫原:

Peptide with sequence C-NQFGKQEPGENSE, from the internal region of the protein sequence according to NP_002075.2.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

偶联:

Unconjugated

产品浓度:

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

TBS, 0.5% BSA, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]

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