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折扣/货期| 货号：24904-10 mg | 规格：10 mg | 目录价：￥3390.2 |
| 货号：24904-25 mg | 规格：25 mg | 目录价：￥8013.2 |
| 货号：24904-5 mg | 规格：5 mg | 目录价：￥1795.6 |
| 货号：24904-50 mg | 规格：50 mg | 目录价：￥14177.2 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
GSK1838705A
产品描述:
An IGF-1R and IR inhibitor (IC50s = 2 and 1.6 nM, respectively); selective for IGF-1R and IR over a panel of 47 kinases (IC50s = >1,600 nM); inhibits ALK (IC50 = 0.5 nM); inhibits ligand-induced phosphorylation of IGF-1R and IR as well as phosphorylation of Akt, IRS-1, and ERK in MCF-7 breast carcinoma cells; inhibits the growth of a panel of cancer cell lines (EC50s = 24-8,378 nM); completely inhibits IGF-1-induced phosphorylation of IGF-IR, Akt, and IRS-1 as well as reduces tumor growth in the COLO 205 and NIH-3T2/LISN mouse xenograft models at ≥1 and ≥10 mg/kg, respectively; induces tumor cell apoptosis and reduces tumor growth in U87MG glioma and PC3R prostate cancer mouse xenograft models
保存温度:
-20
运输温度:
-20
预期分子量:
532.569683
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥95%
CAS号:
1116235-97-2
分子式:
C27H29FN8O3
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