官网链接
折扣/货期| 货号：GTX12168 | 规格：100μl | 目录价：￥6400 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
HDAC1 antibody [HDAC1-21]
别名:
histone deacetylase 1 , GON-10 , HD1 , KDAC1 , RPD3 , RPD3L1
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
ELISA, IP, WB
同种型:
IgG3
免疫原:
synthetic peptide corresponding to amino acids 466-482 of human and mouse HDAC1.
克隆性:
Monoclonal
克隆号:
HDAC1-21
纯化方式:
Purified immunoglobulin
偶联:
Unconjugated
产品浓度:
~2 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
Chromatin is composed of basic repeating units called nucleosomes, which are 146 bp of DNA wound around a histone octamer composed of two each of the core histones H2A, H2B, H3 and H4. Reversible acetylation of highly conserved lysine residues in N-terminal tail domains of core histones plays an important role in transcriptional regulation, cell cycle progression and developmental events. Several histone acetyltransferases (HATs) catalyze the acetylation reaction (GCN5, PCAF, p300/CBP, TAFII250, P/CAF, SRC-1 BRCA-2). Acetylation of the core histones is generally considered to be associated with gene activation, probably through maintenance of the unfolded structure of transcribing nucleosomes. Histone acetylation is a dynamic process whose levels are determined by the net activities of HATs and the competing enzymes histone deacetylases (HDACs). Both activities are associated with the nuclear matrix. Six or seven different mammalian HDACs have been described. HDACs are similar to the yeast Rpd3 protein, while HDACs are similar to the yeast Hda1 protein. Histone deacetylase activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. HDAC1 and 2 are the catalytic subunits of different multiprotein regulatory complexes. The components of such complexes include: corepressors such as mSin3, N-CoR, SMRT, associated proteins such as SAP18, SAP30, RbAp46, RbAp48, c-Ski oncogenic protein, a protein involved in DNA methylation, and more.
您可能感兴趣的产品
H2AX Phospho-Ser 139 (1H2) Monoclonal Antibody
货号：G01106.100 µL
TLF (TBP like factor) Monoclonal Antibody
货号：G01105.100 µL
TIF2 Monoclonal Antibody
货号：G01104.100 µL
TIF2 Monoclonal Antibody
货号：G01103.100 µL
TIF1δ(Transcriptional intermediary factor 1d) Monoclonal Antibody
货号：G01102.100 µL
TIF1 γ Monoclonal Antibody
货号：G01101.100 µL
TIF1 β Monoclonal Antibody
货号：G01100.100 µL
TIF1 α Monoclonal Antibody
货号：G01099.100 µL
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询