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折扣/货期| 货号：GTX75559 | 规格：500μl | 目录价：￥10100 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Her2 / ErbB2 antibody [CB11]
别名:
erb-b2 receptor tyrosine kinase 2 , CD340 , HER-2 , HER-2/neu , HER2 , MLN 19 , NEU , NGL , TKR1
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P
靶标/特异性:
This antibody recognizes human c-erbB-2 oncoprotein (internal domain).
同种型:
IgG1
免疫原:
Synthetic peptide corresponding to a site on the internal domain of the human c-erbB-2 oncoprotein .
克隆性:
Monoclonal
克隆号:
CB11
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Tissue culture supernatant, 0.09% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
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