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折扣/货期| 货号：GTX74708 | 规格：500μl | 目录价：￥5700 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
HLA-B27 antibody [HLA-ABC-m3] (FITC)
别名:
major histocompatibility complex, class I, B , AS , B-4901 , HLAB
反应种属:
Human
宿主来源:
Mouse
实验应用:
FCM
靶标/特异性:
This antibody reacts with the peripheral blood lymphocytes of 47/47 individuals conventionally typed as HLA-B27 + and precipitates cell surface molecules of 43 and 12 kD, corresponding to the HLA Class 1 heavy chain and beta 2 microglobulin.
同种型:
IgG2a
免疫原:
Immune complex precipitated from HLA-B27 positive cell line (Bordin) by anti HLA-antibody and Staphylococcal Protein A.
克隆性:
Monoclonal
克隆号:
HLA-ABC-m3
纯化方式:
Purified by ion exchange chromatography
偶联:
FITC
产品浓度:
50 μg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.2% BSA, 0.1% Sodium azide.
生产商:
GeneTex
功能与背景:
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
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