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折扣/货期| 货号：SPC-181D | 规格：100 µl | 目录价：￥3553.2 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
HSP22 Antibody
别名:
Alpha crystallin C chain Antibody, CMT2L Antibody, CRYAC Antibody, DHMN2 Antibody, H11 Antibody, Heat shock 22kDa protein 8 Antibody, HMN2 Antibody, HSB8 Antibody, HSPB8 Antibody, HSP22 Antibody
产品描述:
Rabbit Anti-Human HSP22 Polyclonal
反应种属:
Human | Mouse | Rat
宿主来源:
Rabbit
实验应用:
WB | IHC | ICC/IF | IP
靶标/特异性:
Detects ~22kDa. Does not cross-react with HSP27 or alpha-crystallin.
推荐稀释度:
WB (1:1000), ICC/IF (1:100), IHC (1:100); optimal dilutions for assays should be determined by the user.
免疫原:
Human HSP22
免疫原种属:
Human
克隆性:
Polyclonal
纯化方式:
Peptide Affinity Purified
偶联:
Unconjugated
产品浓度:
1 mg/ml
保存温度:
-20ºC
运输温度:
Blue Ice or 4ºC
存储溶液:
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
产地:
加拿大
功能与背景:
HSP22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to HSP27. Similar to most other sHSPs, HSP22 is predominately transcribed in skeletal muscle and heart, as well as the placenta (1). HSP22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HSPB8 interacted preferentially with a triple aspartate form of HSP27 which mimics HSP27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type HSP27 (2). HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs (3). The chaperone-like activity is of great importance to the function of HSP22 in various processes including proliferation, apoptosis and macro autophagy (4). Mutations in the HSPB8 gene are associated with the inherited peripheral neuropathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L) (5).
Accession #:
NP_055180.1
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