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折扣/货期| 货号：V7740-100UG | 规格：100 ug | 目录价：￥6652.1 |
| 货号：V7740-20UG | 规格：20 ug | 目录价：￥3082.1 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
HER4 Antibody / ERBB4
产品描述:
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P
同种型:
Mouse IgG1, kappa
免疫原:
A recombinant human partial protein (amino acids 1116-1269) was used as the immunogen for the HER4 antibody.
克隆性:
Monoclonal (mouse origin)
克隆号:
ERBB4/2581
纯化方式:
Protein G affinity chromatography
保存温度:
Store the HER4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
产品形式:
Purified
存储溶液:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
产地:
美国
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