Hsp90 beta antibody-多抗-深圳欣博盛生物科技有限公司

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Hsp90 beta antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX79247

规格：100μg

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Hsp90 beta antibody

别名:

heat shock protein 90 alpha (cytosolic), class B member 1 , 90kDa , AL022974 , C81438 , Hsp84 , Hsp84-1 , Hsp90 , Hspcb

反应种属:

Human, Mouse, Primate, Rat

宿主来源:

Rabbit

实验应用:

FCM, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB

靶标/特异性:

This antibody does not detect HSP86. The antibody is capable of precipitating HSP84 that is complexed with other proteins such as the aryl hydrocarbon (Ah) receptor.

同种型:

IgG

免疫原:

Synthetic peptide corresponding to residues P(2) E E V H H G E E E V E(13) of mouse HSP84.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

Buffer, 0.1% BSA, 0.05% Sodium azide.

生产商:

GeneTex

功能与背景:

Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases. Studies have shown that murine HSP90 exists as two forms, HSP84 and HSP86, coded by related but separate genes, with 86% amino acid sequence conservation. These forms are analogous to the two forms of human HSP90, HSP89 alpha and HSP89 beta. In an unstressed mouse fibroblast, the basal level of HSP84 is found to be double that of HSP86. However, after heat shock, HSP86 shows a greater increase. Studies also suggest that upon cellular differentiation, the level of HSP86, but not HSP84, decreases. HSP84 and HSP86, which may be subject to estrogenic regulation, have been found as components of the non-DNA binding form of mouse glucocorticoid receptor, but dissociated from the transformed DNA-binding form.

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