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折扣/货期| 货号：GTX136908-pro | 规格：500μg | 目录价：￥2300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Human ApoE4 protein
别名:
apolipoprotein E , AD2 , APO-E , ApoE4 , LDLCQ5 , LPG
产品描述:
APOE belongs to the apolipoprotein family and is a 299 a.a. protein with three allelic variants that give rise to the APOE 2, APOE 3, and APOE 4 isoforms. APOE is directly involved in lipoprotein metabolism and functions as a ligand for multiple receptors (e.g., the LDL receptor). These isoforms are critical for brain homeostasis and, while APOE 2 was shown to be protective in terms of Alzheimer’s disease (AD) risk, the 34.4 kDa APOE 4 isoform is a major risk factor for late-onset AD.
克隆号:
偶联:
Unconjugated
产品浓度:
表达系统:
E. Coli
保存温度:
Store at 4ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. For long-term storage after reconstitution, aliquot and store at -70ºC or below. Do not vortex.
运输温度:
4°C
产品形式:
Lyophilized powder
存储溶液:
Reconstitute with distilled water to 0.1 mg/ml. Lyophilized from 50mM PBS, 100mM NaCl, 5% Trehalose, no preservatives.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
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