Human Recombinant Alpha Synuclein Oligomers (Kinetically Stable)-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Alpha Synuclein Oligomers (Kinetically Stable)

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-484C

规格：100 µg x2

目录价：￥18963

产品详情

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产品名称:

Human Recombinant Alpha Synuclein Oligomers (Kinetically Stable)

别名:

Alpha synuclein pre-formed fibrils, Alpha synuclein aggregates, Alpha synuclein protein aggregates, Alpha synuclein aggregates, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkison disease familial 1 Protein

产品描述:

Human Recombinant Alpha Synuclein Oligomers (Kinetically Stable)

反应种属:

Human

实验应用:

WB | Native PAGE | In vivo assay | In vitro assay

纯化方式:

Ion-exchange Purified, monomer removed with 100K MWCO filter

偶联:

No Tag

产品浓度:

2 mg/ml

表达系统:

E. coli

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

650-1200 kDa

存储溶液:

PB pH 7.4 (10 mM KH2PO4, 7.5 mM NaOH, pH 7.4)

产地:

加拿大

功能与背景:

Our kinetically stable oligomers of alpha-synuclein are generated without an inducer or inhibitor and remain stable for at least 2 weeks at 37oC. They present as globular structures under TEM, demonstrate toxicity in rat primary dopaminergic neurons and induce Parkinson’s-associated alpha synuclein phosphoserine 129 pathology. These oligomers have been previously characterized as globular, cylindrical structures with a beta-sheet structure intermediate between monomers and fibrils, and were demonstrated to have a higher toxicity to neurons than alpha-synuclein fibrils (1,2). Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (3). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (4). Functionally, it has been shown to significantly interact with tubulin (5), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (6). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimer’s disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (7, 8).

纯度:

>95%

Accession #:

NP_000336.1