Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2)-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2)

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-317C

规格：100 µg x2

目录价：￥8820

产品详情

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产品名称:

Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2)

别名:

Alpha synuclein PFFs, Alpha synuclein PFF, Alpha synuclein aggregates, Alpha synuclein protein aggregates, Alpha synuclein aggregates, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson disease familial 1 Protein

产品描述:

Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2)

反应种属:

Human

实验应用:

WB | SDS-PAGE | In vivo assay | In vitro assay

纯化方式:

Ion-exchange Purified

偶联:

No tag

产品浓度:

2 mg/ml

表达系统:

E. coli

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

~14.46 kDa

存储溶液:

PBS pH 7.4

产地:

加拿大

功能与背景:

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).

纯度:

>95%

生物活性:

Does not induce Lewy body inclusion formation in Sprague-Dawley rat primary hippocampal neurons. Thioflavin T emission curve shows only a small increase in fluorescence (indicative of alpha synuclein aggregation) when Type 2 alpha synuclein PFFs (SPR-317) are combined with alpha synuclein monomers (SPR-321 or SPR-316). Certain biological activities in other neuronal cells cannot be ruled out. Researchers should test compatibility prior to use.

Accession #:

NP_000336.1