Human Recombinant Alpha Synuclein S129A Mutant Monomers-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Alpha Synuclein S129A Mutant Monomers

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-505C

规格：100 µg x2

目录价：￥8694

产品详情

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产品名称:

Human Recombinant Alpha Synuclein S129A Mutant Monomers

别名:

Alpha synuclein protein, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson's disease familial 1 Protein, Alpha Synuclein S129A

产品描述:

Human Recombinant Alpha Synuclein S129A Mutant Monomers

反应种属:

Human

实验应用:

WB | In vivo Assay | In vitro Assay

纯化方式:

Ion-exchange Purified

偶联:

No Tag

产品浓度:

2 mg/ml

表达系统:

E. coli

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

14.44 kDa

存储溶液:

1X PBS pH7.4

产地:

加拿大

功能与背景:

Elevated levels of phosphoserine 129 (pS129) on alpha-synuclein has long been considered a hallmark of Parkinson’s disease and other synucleinopathies, where up to 90% of alpha-synuclein deposition in Lewy Bodies contains pS129, compared to ≤4% in normal brains (reviewed in [1]). Further, pS129 was recently shown to function as a physiological regulator of neuronal activity (2). Alpha-synuclein S129A monomers and fibrils cannot be phosphorylated at position 129, and therefore can be utilized to study phospho-S129-independent biology and pathology. Further, this material can be used to confirm induction of endogenous pS129 pathology in disease models.

纯度:

>95%