Human Recombinant Alpha Synuclein S87N Mutant Monomers-其他重组蛋白-深圳欣博盛生物科技有限公司

首页产品中心其他重组蛋白

Human Recombinant Alpha Synuclein S87N Mutant Monomers

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-499XE

规格：500 µg (@5mg/ml)

目录价：￥18081

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Recombinant Alpha Synuclein S87N Mutant Monomers

别名:

Alpha Synuclein S87N, Alpha synuclein protein, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson's disease familial 1 Protein

产品描述:

Human Recombinant Alpha Synuclein S87N Mutant Monomers

反应种属:

Human

实验应用:

WB | SDS PAGE | In vitro Assay

纯化方式:

Ion-exchange Purified

偶联:

No Tag

产品浓度:

2 mg/ml or 5 mg/ml

表达系统:

E. coli

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

14.46 kDa

存储溶液:

1X PBS pH 7.4

产地:

加拿大

功能与背景:

Human alpha synuclein S87N mutant (HuS87N) has Ser87 mutated to the equivalent mouse residue Asn87, effectively making it a human-mouse chimeric protein. Despite sequence differences at only seven residues, or 5% of the total 140 amino acids, the aggregation rate of wild-type mouse α-syn (MsWT) is faster than wild-type human α-syn (HuWT) in vitro. In wild-type mouse models, MsWT fibrils are more efficient than HuWT fibrils at inducing pathology of endogenous mouse α-syn (1). A53T or S87N substitutions in human α-syn substantially accelerate fibrilization rates in vitro (2,3). Chimeric HuS87N fibrils show enhanced pathogenicity to wild-type mouse neurons, greater than HuWT, HuA53T, and MsWT fibrils (4). HuS87N fibrils can be used as a more human-like alternative to MsWT fibrils to induce equivalent or greater endogenous α-syn seeding and pathology in wild-type mice.

纯度:

>95%

Accession #:

NP_000336.1