Human Recombinant GRP78 (Bip) Full Length Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant GRP78 (Bip) Full Length Protein

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-119B

规格：100 µg

目录价：￥4246.2

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Recombinant GRP78 (Bip) Full Length Protein

别名:

BIP Protein, Grp78 Protein, HSPA5 Protein, MIF2 Protein, immunoglobulin heavy chain binding Protein

产品描述:

Human Recombinant GRP78 (Bip) Full Length Protein

反应种属:

Human

实验应用:

WB | SDS-PAGE | ATPase Activity Assay | Functional Assay | ELISA

纯化方式:

Affinity Purified

偶联:

No tag

产品浓度:

Lot/batch specific. See included datasheet.

表达系统:

E. coli

保存温度:

-20ºC

运输温度:

Blue Ice or 4ºC

预期分子量:

~78 kDa

存储溶液:

20mM Tris/HCl pH7.5, 50mM KCl, 5mM MgCl2, 1mM DTT

产地:

加拿大

功能与背景:

GRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1). GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3). In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia (Barnes), to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer's patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7).

纯度:

>90%

Accession #:

NM_005347

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